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Research Publications

Original Research Articles (peer-reviewed)

Guo, X., Ji, N., Guo, Q., Wang, M., Du, H., Pan, J., Xiao, L., Gupta, N*, Feng, Y., & Xia, N. (2024) PMID: 38589375

Metabolic plasticity, essentiality and therapeutic potential of ribose-5-phosphate synthesis in Toxoplasma gondii. Nature communications, 15(1), 2999


Katelas DA, Cruz-Miron R, Arroyo-Olarte RD, Brouwers JF, Srivastav RK, Gupta N* (2024) PMID: 38522751

Phosphatidylserine Synthase in the Endoplasmic Reticulum of Toxoplasma is Essential for its Lytic Cycle in Human Cells. Journal Lipid Research, 22:100535

Fan F, Xue L, Yin X, Gupta N, Shen B* (2023) PMID: 37750704

AP2XII-1 is a negative regulator of merogony and pre-sexual commitment in Toxoplasma gondii, mBio, e0178523

Ren B, Liang X, Cruz-Miron R, Brouwers JF, Shen B*, Gupta N* (2023) PMID: 36949328
Synthesis versus salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondii. Communications Biology, 6(1), 306

Lyu C, Chen Y, Meng Y, Yang J, Ye S, Niu Z, EI-Debs I, Gupta N*, Shen B* (2023) PMID: 36920199
The mitochondrial pyruvate carrier coupling glycolysis and the TCA cycle is required for the asexual reproduction of Toxoplasma gondii. Microbiology Spectrum, e05043-22


Chen K, Huang X, Distler U, Tenzer S, Günay-Esiyok Ö, Gupta N* (2023) PMID: 36936814
Apically-located P4-ATPase1-Lem1 complex internalizes phosphatidylserine and regulates motility-dependent invasion and egress in Toxoplasma gondii. Computational and Structural Biotechnology Journal, 21, 1893-1906 


Salama DB, Fereig RM, Abdelbaky HH, Shahat MS, Arafa WH, Aboelhadid SM, Mohamed AEA, Metwally S, Abas O, Suo X, Gupta N, Frey CF* (2022) PMID: 36558798

Toxoplasma gondii and Neospora caninum antibodies in dogs and catsfrom Egypt and risk factor analysis. Pathogens, 11(12), 1464


Vo KC, Ruga L, Psathaki OE, Franzkoch R, Distler U, Tenzer S, Hensel M, Hegemann P, Gupta N* (2022) PMID: 36382189
Plasticity and Therapeutic Potential of cAMP and cGMP-specific Phosphodiesterases in Toxoplasma gondii. Computational and Structural Biotechnology Journal, 20, 5775-5789


Wang C, Liu L, Wang T, Liu X, Peng W, Srivastav RK, Zhu XQ, Gupta N, Gasser RB*, Hu M* (2022) PMID: 36405717
H11-induced immunoprotection is predominantly linked to N-glycan moieties during Haemonchus contortus infection. Frontiers in Immunology, 13:1034820

Xia N, Guo X, Guo Q, Gupta N, Ji N, Shen B*, Xiao L*, Feng Y* (2022) PMID: 36121870
Metabolic flexibilities and vulnerabilities in the pentose phosphate pathway of the zoonotic pathogen Toxoplasma gondii. PLoS pathogens, 18(9), e1010864

Wang C, Gao W, Yan S, Zhang T, Zhu X-Q, Suo X, Liu X, Gupta N, Hu M* (2021) PMID: 34025939
N-glycome and N-glycoproteome of a hematophagous parasitic nematode Haemonchus. Computational & Structural Biotechnology Journal, 19, 2486-96


Chen K, Günay-Esiyok Ö, Klingeberg M, Marquardt S, Günther-Pomorski T, Gupta N* (2021) PMID: 33485966

Aminoglycerophospholipid flipping and P4-ATPases in Toxoplasma gondii. Journal of Biological Chemistry, 296, 100315


Ren B, Schmid M, Scheiner M, Mollenkopf HP, Lucius R, Heitlinger E, Gupta N* (2021) PMID: 33510872

Toxoplasma and Eimeria co-opt the host cFos and its network proteins in mammalian cells. Computational & Structural Biotechnology Journal, 19, 719-31 


Li F, Qing P, Ye L, Gupta N, Hu M* (2021) PMID: 33553419
A novel BR-SMAD protein controls the larval development in barber’s pole worm Haemonchus contortus. Microbial Cell, 8(2), 57-64


Ren B, Kong P, Hedar F, Brouwers JF, Gupta N* (2020) PMID: 33303967
Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii. Communications Biology, 3(1), 750


Vo Kim Chi, Günay-Esiyok Ö*, Liem N, Gupta N* (2020) PMID: 33335684
The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells. Computational & Structural Biotechnology Journal, 18, 3861-76

Zhou H, Zhou T, Zhang B, Lei W, Yuan W, Shan J, Zhang Y, Gupta N, Hu M* (2020) PMID: 32592810
RIOK-2 is essential for egg hatching in a common parasitic nematode. International Journal of Parasitology, S0020-7519(20)30152-1


Liang X, Cui J, Yang X, Xia N, Li Y, Zhao J, Gupta N*, Shen B* (2020) PMID: 32341123
Acquisition of exogenous fatty acids renders the apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma gondii. Journal of Biological Chemistry, 295(22):7743-7752

Günay-Esiyok Ö, Scheib U, Noll M, Gupta N* (2019) PMID: 31235476

An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist. Life Science Alliance, 2 (3) pii. e201900402


Xia N, Ye S, Liang X, Fang R, Zhou Y, Zhao J, Gupta N, Yang S, Yuan J, Shen B* (2019) PMID: 31186321
Pyruvate homeostasis as a determinant of parasite growth and metabolic plasticity in Toxoplasma gondii. mBio, 10(3). pii: e00898-19


Figueiredo CA, Düsedau HP, Steffen J, Gupta N, Dunay MP, Toth G, Reglödi D, Heimesaat MM, Dunay IR* (2019) PMID: 31192159
Immune-modulatory effects of the neuropeptide pituitary adenylate cyclase-activating polypeptide in acute Toxoplasmosis. Frontiers in Cellular and Infection Microbiology, 9:154


Erler H, Ren B, Gupta N*, Beitz E* (2018) PMID: 30237165
Intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and L-lactate transporters in the plasma membrane. Journal of Biological Chemistry, 293(45), 17622-17630


Kong P, Lehmann MJ, Helms BJ, Brouwers JF, Gupta N* (2018) PMID: 29844921
Lipid analysis of Eimeria sporozoites reveals exclusive phospholipids, a phylogenetic mosaic of endogenous synthesis, and a host-independent lifestyle. Cell Discovery, 4:24

Narvaez-Ortiz HY, Lopez AJ, Gupta N*, Zimmermann BH* (2018) PMID: 29623259
A CTP synthase undergoing stage-specific reorganization is essential for the survival of the intracellular parasite Toxoplasma gondii. Frontiers in Cellular and Infection Microbiology, 8:83


Huang G, Zhang S, Zhou CX, Tang X, Li C, Wang C, Tang X, Suo JX, Jia Y, Saeed E-A, Cai J, Yu Z, Cai J, Gupta N, Suo X, Liu X* (2018) PMID: 29440368
Influence of Eimeria falciformis infection on gut microbiota and metabolic pathways in mice. Infection and Immunity, pii: 00073-18

Nitzsche N§, Günay-Esiyok O§, Tischer M, Zagoriy V, Gupta N* (2017) PMID: 28726641
A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii. Journal of Biological Chemistry, 292(37), 15225-39


Kong P, Ufermann CM, Zimmermann DLM, Yin Q, Suo X, Helms JB, Brouwers JF, Gupta N* (2017) PMID: 28314772
Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii. Journal of Biological Chemistry, 292(17), 7145-59


Sugi T, Ma YF, Tomita T, Murakoshi F, Eaton MS, Yakubu R, Han B, Tu V, Kato K, Kawazu SI, Gupta N, Suvorova ES, White MW, Kim K, Weiss LM* (2016) PMID: 27247232
Toxoplasma gondii cAMP-dependent protein kinase subunit 3 is involved in the switch from tachyzoite to bradyzoite development. mBio, 7(3), e00755-16


Kuchipudi A, Arroyo-Olarte RD, Hoffmann F, Brinkmann V, Gupta N* (2016) PMID: 28357357
Optogenetic monitoring of the parasite calcium identifies a phosphatidylthreonine-regulated ion homeostasis in Toxoplasma gondii. Microbial Cell, 3(5), 215-23

Nitzsche R, Zagoriy V, Lucius R, Gupta N* (2016) PMID: 26518878
Metabolic cooperation of glucose and glutamine is essential for the lytic cycle of obligate intracellular parasite Toxoplasma gondii. Journal of Biological Chemistry, 291(1), 126-41


Arroyo-Olarte RD, Burrowers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N* (2015) PMID: 26565995
Phosphatidylthreonine and lipid-mediated control of parasite virulence. PLoS Biology, 13(11), e1002288


Blume M, Nitzsche R, Sternberg U, Gerlic M, Masters SL, Gupta N, McConville MJ* (2015) PMID: 26269956
A Toxoplasma gondii gluconeogenic enzyme contributes to robust central carbon metabolism and is essential for replication and virulence. Cell Host & Microbe, 18(2), 210-20


Hartmann A, Hellmund M, Lucius R, Voelker DR, Gupta N* (2014) PMID: 24429285
Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii. Journal of Biological Chemistry, 289(10), 6809-24

Schmid M, Heitlinger E, Spork S, Mollenkopf HP, Lucius R, Gupta N* (2014) PMID: 24368565
Eimeria falciformis infection of the mouse caecum identifies opposing roles of IFNg-regulated host pathways for the parasite development. Mucosal Immunology, 7(4), 969-82

Hartmann A§, Arroyo-Olarte RD§, Imkeller K, Hegemann P, Lucius R, Gupta N* (2013) PMID: 23525100
Optogenetic modulation of an adenylate cyclase in Toxoplasma gondii demonstrates a requirement of parasite cAMP for host-cell invasion and stage differentiation. Journal of Biological Chemistry, 288(19), 13705-17

Qureshi B§, Hoffmann N§, Arroyo-Olarte RD, Nickl B, Höhne W, Jungblut P, Lucius R, Scheerer P*, Gupta N* (2013) PMID: 23233536
Dynein Light Chain 8a of Toxoplasma gondii, a unique conoid-localized β-strand-swapped homodimer, is required for an efficient parasite growth. FASEB Journal, 27(3), 1034-47


Gupta N*, Hartmann A, Lucius R, Voelker DR* (2012) PMID: 22563079 
The obligate intracellular parasite Toxoplasma gondii secretes a soluble phosphatidylserine decarboxylase. Journal of Biological Chemistry, 287(27), 22938-47

Schmid M, Lehmann MJ, Lucius R, Gupta N* (2012) PMID: 22535959
Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in the mouse. Journal of Biological Chemistry, 287(24), 20197-207

Sampels V, Hartmann A, Dietrich I, Coppens I, Sheiner L, Striepen B, Herrmann A, Lucius R, Gupta N* (2012) PMID: 22451671
Conditional mutagenesis of a novel choline kinase demonstrates the plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii. Journal of Biological Chemistry, 287(20), 16289-99

Blume M, Hliscs M, Contreras D, Sanchez M, Landfear S, Lucius R, Matuschewski K, Gupta N* (2011) PMID: 21169382
A constitutive pan-hexose permease in Plasmodium and models for high-throughput screening of anti-malarial sugar analogs. FASEB Journal, 25(4), 1218-29


Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, Qiao A, Kong X, Liu Y, Chen Q, Gupta N, Fang F, Chang Y* (2010) PMID: 20561910
PGC-1b-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERRa. Mitochondrion, 10(5), 516–27

Zhu LL, Liu Y, Cui AF, Shao D, Liang JC, Liu XJ, Chen Y, Gupta N, Fang FD, Chang Y* (2010) PMID: 20215575
PGC-1a coactivates estrogen receptor a to induce the expression of glucokinase. American Journal of Physiology Endocrinology Metabolism, 298(6), E1210–8

Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y* (2009) PMID: 19602572
Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Molecular Pharmacology, 76(4), 854-60

Blume M, Contreras DR, Landfear S, Fleige T, Soldati DF, Lucius R, Gupta N* (2009) PMID: 19617561
Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. Proceedings of National Academy of Sciences USA, 106(31), 12998–3003


Liu X, Feng Q, Chen Y, Zuo J, Gupta N, Chang Y*, Fang F (2009) PMID: 19125585
Proteomics-based identification of differentially-expressed proteins including galectin-1 in the blood plasma of type 2 diabetic patients. Journal of Proteome Research, 8(3), 1255-62

Jiang ZB, Song HT, Gupta N, Ma LX, Wu ZB* (2007) PMID: 17709259
Cell surface display of functionally active lipases from Yarrowia lipolytica in Pichia pastoris. Protein Expression Purification, 56(1), 35-9


Yang C, Yang Y, Gupta N, Liu X, He A, Liu L, Zuo J, Chang Y*, Fang F (2007) PMID: 17922643
Pentaspan membrane glycoprotein, prominin-1, is involved in glucose metabolism and cytoskeleton alteration. Biochemistry (M), 72(8), 854-62

He A, Zhu L, Gupta N, Chang Y*, Fang F (2007) PMID: 17652184
Overexpression of miR-29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Molecular Endocrinology, 21(11), 2785-94

Liu XJ, Yang C, Gupta N, Zuo J, Chang YS*, Fang FD (2007) PMID: 17619838
Protein kinase C-ζ regulation of GLUT4 translocation by actin remodeling in CHO cells. Journal of Molecular Medicine, 85(8), 851–61

Gupta N, Zahn MM, Coppens I, Joiner KA, Voelker DR* (2005) PMID: 15708856
Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. Journal of Biological Chemistry, 280(16), 16345–53 

Review and Perspective Articles (peer-reviewed)

Günay-Esiyok Ö*, Gupta N* (2020) PMID: 32191852
Chimeras of P4-ATPase and guanylate cyclase in pathogenic protists. Trends in Parasitology, 36 (4), 382-92

Arroyo-Olarte RD, Thurow L, Kozjak-Pavlovic V, Gupta N* (2018) PMID: 30001435
Illuminating pathogen-host intimacy through optogenetics. PLoS Pathogens, 14 (7): e1007046

Ren B, Gupta N* (2017) PMID: 28730142
Taming parasites by tailoring them. Frontiers in Cellular and Infection Microbiology, 7 (292), 1-7

Arroyo-Olarte RD and Gupta N* (2016) PMID: 28357353
Phosphatidylthreonine: an exclusive phospholipid regulating calcium homeostasis and virulence in a parasitic protest. Microbial Cell, 3(5), 189-90


Other Publications (feature articles in science magazines)

Gupta N* (2018) Optobiology in infection: Host-pathogen interplay in the limelight. EU Research (PDF)

Gupta N* (2013) Exploiting the Host: Parasite-host interactions. International Innovation (PDF)

*  Communication authorship                 § Equal contribution authors 


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