Lipid Biogenesis
Research Focus​
We investigate lipid metabolism, focusing on cleavage products from lipolytic enzymes and their regulatory roles. Utilizing advanced lipidomics and imaging tools, we map lipid biosynthetic pathways and explore their influence on parasite propagation. Collaborations with international experts further enrich our studies, enabling deeper insights into lipid-mediated processes.
Introduction
Toxoplasma gondii invades nucleated cells and multiplies rapidly, relying on phospholipids for replication and membrane formation. The essential phospholipids include phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PT), which are synthesized through specific biosynthetic pathways. Recent studies have advanced the understanding of lipid biogenesis in Toxoplasma gondii and its role in parasite survival and virulence.
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Team: Lipd Lovers​
The team comprises doctoral scholars and research associates, each focusing on distinct aspects of Toxoplasma’s lipid metabolism and signaling.
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Dr. Ratnesh oversees the projects on lipid biosynthesis and metabolism.
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Aditi studies the sphingolipid synthesis pathway and its physiological significance in Toxoplasma gondii.
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Namita focuses on characterizing phospholipases in Toxoplasma gondii and exploring their functional relevance.
Together, the team integrates experimental and computational methodologies to elucidate the roles of lipids in parasite biology.